The activity of the lab is focused on the functional dissection of signal transduction pathways in lymphocyte activation and apoptosis and dysregulation of these processes un lymphoproliferative, autoimmune, immunodeficiency and pathogen-related diseases.
Current research topics include:
-Characterization of the Shc family of protein adapters in the immune system, with a focus on their role as negative regulators of autoimmunity and leukemia
-Regulation of membrane trafficking at the immune synapse by the intraflagellar transport system
-Modulation of antigen receptor signaling and immune synapse assembly by bacterial toxins as a strategy of immune evasion