General and Inorganic Chemistry, Analytical Chemistry 1 and Mathematics are strongly suggested
The aim of the didactic activity is to provide the students with the principles of chemical-physic to understand the nanocarriers systems, together with the adequate tools to understand the fundamental concepts of formulation, preparation and control of biocarriers.
Drug delivery systems and nanocarriers
Introduction to drug delivery methods.
Nanocarriers: Physical-chemistry properties. Methods of production. Stability and storage.
Liposomes: chemical characteristics and classification. Chemical properties. Methods of production. Stability and storage.
Characterization: Microscopy techniques (scanning electron microscopy SEM, transmission electron microscope TEM, atomic force microscope AFM).
Thermodynamic characterization by differential scanning calorimetry DSC. Physical-chemistry characterization: zeta potential, dynamic light scattering DLS, Nuclear magnetic resonance NMR, infrared and UV-vis spectroscopy.
Determination of encapsulation efficiency. Mechanics and dynamics simulations.
Drugs Release: classical methods and examples.
Wilson C. G., Crowley P. J., Controlled Release in Oral Drug Delivery, Springer, 2011
Li X., Design of Controlled Release Drug Delivery Systems, McGraw-Hill, 2005
Theoretical lessons on physical-chemistry
aspects of drug delivery systems
Oral exam (questions both on theoretical and applications issues) to verify the theoretical knowledge of the topics
The teacher will be glad answering any question via e-mail email@example.com or during meetings previously scheduled.