SCIENTIFIC PROGRAMME

Saturday May 29th 2010
   
14.00

Registration and coffee
14.45

Welcome

15.00 – 19.00 CNS:
Chair: Anita Sidhu
15.00 – 15.30 Karen Chen: "Spinal muscular atrophy: an overview from genetics to therapeutics"
15.30 – 16.00 Clark Eid: "Pyranoquinone Lactones:  A New Class of AKT Selective Kinase Inhibitors"
16.00 – 16.30 Allen B. Reitz:"New approaches for the treatment of Amyotrophic Lateral Sclerosis"
16.30 – 17.00 Robert H. Ring: "Discovery and Development of Therapeutics for Autism Spectrum Disorders: Challenges, misconceptions, and the path forward"
17.00 – 17.30 coffee break

Chair: Karen Chen
17.30 – 18.00 Roberto Pellicciari:"Nuclear Receptors as Targets for Neglected and Orphan Diseases. Focus on FXR and Related Bile Acids Receptors"
18.00 – 18.30

Joe G.N. Garcia:"Genomic strategies for drug target identification in orphan lung diseases"
18.30 – 19.00 Anita Sidhu: "GSK-3beta inhibitors in treatment of Parkinson's disease"
19.00 welcome cocktail
   
Sunday May 30th 2010
   
9.00 – 11.30 TB

Chair: Martin Pomper
9.00 – 9.30 William Bishai:"Synthetic lethality in M. tuberculosis: harnessing beta-lactams to treat TB"
9.30 – 10.00 Mariangela Biava:"New pyrrole derivatives of BM 212: a new class of antimycobacterial agents. Design, synthesis, biological evaluation and study of their mode of action"
10.00 – 10.30 coffee break

Chair: William Bishai
10.30 – 11.00 Martin Pomper:"Translational molecular imaging of infectious diseases"
11.00 – 11.30 Samuel Raj:"Ribosome Recycling Factor (RRF) as an attractive antibacterial target with special reference to the intracellular pathogen Mycobacterium tuberculosis"
11.30 – 12.00 Hanoch Senderowitz: "Computer Aided Drug Discovery: Methodologies, Challenges and Applications in the Cystic Fibrosis Arena"
12.30 lunch
15.00 – 17.00 Poster session and selection for short talks
17.00 – 17.30 coffee break
17.30 – 19.00 TROPICAL/PARASITIC AND NEGLECTED DISEASES

Chair: Simon Croft
17.30 – 18.00 Geoffrey Dow:"Malaria as a multi-spectrum disease: targeting of medicinal chemistry efforts for multiple indications"
18.00 – 18.30 David Waterson:"Targeting Malaria: medicinal chemistry challenges"
18.30 – 19.00

Martin Pan:"Dose ranking and strategic choices in clinical development of antimalarials. How translational models can better guide clinical studies"
   
Monday May 31st 2010
   
9.00 – 12.00 TROPICAL/PARASITIC AND NEGLECTED DISEASES

Chair: Geoffrey Dow
9.00 – 9.30 Shah Makujina:"Neglecting Patents not Tropical Diseases"
9.30 – 10.00 Maria Laura Bolognesi: "Multitarget Ligands in the Search for Novel Lead Candidates against Trypanosoma and Leishmania"
10.00 – 10.30 Simon Croft:"Drug development for leishmaniasis and trypanosomiasis - need for new models and perspectives"
10.30 – 11.00 coffee break

Chair: Patrick Woster
11.00 – 11.30 Patrick Woster:"Substituted guanidines, biguanides and their isosteres as potential treatments for trypanosomiasis, leishmaniasis and malaria"
11.30 – 12.00 Allan Saul: "Novartis Vaccines Institute for Global Health: An industry based concept for developing vaccines for neglected diseases"
12.00 – 12.30 Jimmy Orjala: "Cyanobacteria as a source for Natural Products for Neglected Diseases"
13.00 lunch
12.30 – 13.00 Walter Cabri: "Eurartesim a new ACT combination Therapy"
15.00 – 17.00 RETT

Chair: Antony Horton
15.00 – 15.30 Antony Horton:"A Strategic Analysis of International Research & Funding for the Rett Syndrome Field"
15.30 – 16.00 Alessandra Renieri: "Rett syndrome: from clinics to research and viceversa"
16.00 – 16.30

Karol S. Bruzik: "Phosphatidylinositol-Specific Phospholipase C from Streptomyces: Unique Mechanism and Substrate Specificity"
16.30– 17.00 coffee break
17.00 – 18.00 HUNTINGTON'S DISEASE

Chair: Georg C. Terstappen
17.00 – 17.30

Andrea Caricasole: "Drug target discovery for HD in the postgenomic era"
17.30 – 18.00 Georg C. Terstappen: "Development of novel pharmaco-therapies for HD"
   
Tuesday June 1st 2010
   
9.00 – 11.30    Last minute invitations and poster session selected (young scientists)

Chair: Maurizio Botta
9.00 – 9.30

Menico Rizzi: "Structural biology of NAD biosynthesis: a promising target for the treatment of Malaria and Tuberculosis"
9.30 – 10.00

Leopold Flohe: "In search of drugs for trypanosomiasis and leismaniasis based on inhibition of the trypanothione system"
10.00 – 10.30 coffee break

Chair: Menico Rizzi
10.30 – 11.00 Jacob Golenser: "Artemisone is effective against murine cerebral malaria (CM), and is synergistic with chloroquine"
11.00 – 11.30

Antoniana U Krettli: "Antimalarial activities of bioproducts from medicinal plants and from synthethic primaquine, mefloquine, artemisinine derivatives"
12.30     Departure