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Università degli Studi di Siena
I EWDSy
First European Workshop in Drug Synthesis
May, 14 – 20, 2006 – Certosa di Pontignano, Siena (Italy)
Programme
Sunday, May 14
16.00: registration
20.00: dinner
21.00: welcome
Monday 15 (Synthesis of Drugs)
Chairman: Leon Ghosez (European Institute of Chemistry and Biology, Pessac-France)
9.00 – 9.50: Stephen Hanessian (Université de Montréal – Canada; University of California, Irvine - USA) : “Structure-based Organic Synthesis toward Enzyme Inhibitors”
10.00 – 10.50: Giovanni Appendino (Università del Piemonte Orientale, Italy): “Non multa sed multum. Chasing quality over quantity: natural products as privileged structures for drug discovery”
11.00 – 11.20: coffee break (sponsored by StepBio s.r.l.)
Chairman: Henk Timmerman (Vrije Universiteit Amsterdam - the Netherlands)
11.30 – 12.20: Erick Carreira (ETH Zurich - CH): “Studies in Synthesis”
13.00: lunch
Chairman: Andreas Kirschning (University of Hannover, Germany)
15.00 – 15.50: Cristina Martins (School of Pharmacy, London - UK): “Rational Design and Synthesis of DNA Quadruplex Anti-cancer Agents: Case study of an Academic-industrial collaboration”
16.00 – 16.20: coffee break
16.30: exercises: Gianluca Papeo (Nerviano Medical Sciences) – Stephen Hanessian (Université de Montréal – Canada; University of California, Irvine - USA)
20.00: dinner
21.00: wine tasting (sponsored by Biotage s.r.l.)
Tuesday 16 (Synthesis of Drugs)
9.00 – 9.50: Leon Ghosez (European Institute of Chemistry and Biology, Pessac-France) : "Tools for Diversity-Oriented Synthesis"
10.00 – 10.50 : Urszula Grabowska (Medivir – UK): “Design of Cathepsin K Inhibitors”
11.00 – 11.20: coffee break (sponsored by CEM s.r.l.)
Chairman: Giovanni Appendino (Università del Piemonte Orientale, Italy)
11.30 – 12.20: Christopher Moody (University of Nottingham - UK): "Synthesis of substrates and inhibitors of quinone reductases"
13.00: lunch
Steve’s Afternoon: 70’s birthday
Introducing: Sergio Penco
15.00 – 15.30: Marino Petrini (Università di Camerino – Italy): “Nitroalkanes as Versatile Reagents in Synthesis”
15.40 – 16.10: Walter Cabri (Antibioticos s.p.a. – Italy): “Green Chemistry in the Pharmaceutical Industry”
16.20 – 16.40: coffee break
16.45 – 17.15: Romano Di Fabio (Glaxo Smith Kline – Italy): to be defined
poster session
20.00: dinner at Piazza del Campo - Siena
Wednesday 17 (Discovery in Medicinal Chemistry)
Chairman: Urszula Grabowska (Medivir – UK)
9.00 – 9.50: Henk Timmerman (Vrije Universiteit Amsterdam - the Netherlands): "Histamine receptors and their ligands; valuable tools for medicines research"
10.00 – 10.50: Dieter Schinzer (Magdeburg University - Germany): “Epothilones: A New Class of Powerful Antitumor Drugs”
11.00 – 11.20: coffee break
Chairman: Cristina Martins (School of Pharmacy, London - UK)
11.30 – 12.20: Roberto Pellicciari (Università di Perugia – Italy): “Drug Discovery with The Farnesoid X Receptor (FXR) as Target. From Functions Unraveling to Therapeutic Exploitation”
13.00: lunch
15.00 – 15.50: Robert R. Rando (Harvard Medical School – USA): “Chemical Biological Approaches to Vision and Small Molecule Approaches to the Treatment of Macular Degeneration"
16.00 – 16.20: coffee break
16.30: Round table on the Future in Medicinal Chemistry
Introducing: Germano Carganico (Toscana Life Sciences Foundation- Italy)
20.00: dinner
Chairman: Maurizio Botta (Università di Siena – Italy)
21.00: Hugo Kubinyi (Germany) : “Combinatorial Chemistry in Drug Research”
Thursday 18 (Supported Reagents in Organic Synthesis)
Chairman: Lester Marrison (Evotec OAI)
9.00 – 9.50: Bruno Linclau (University of Southampton, UK): “An introduction to phase-separation techniques for solution phase chemistry”
10.00 – 10.50: Philip Hodge (University of Manchester, UK): “Organic Synthesis using Bench-top Flow Systems”
11.00 – 11.20: coffee break
11.30 – 12.20: Andreas Kirschning (University of Hannover, Germany): “Chemistry in Flow – Enabling Technologies in Organic Synthesis using PASSflow reactors”
13.00: lunch
15.00: lab session at University of Siena
20.00: social dinner
Friday 19 (Supported Reagents in Organic Synthesis)
Chairman: Chiara Ghiron (Siena Biotech s.p.a. – Italy)
9.00 – 9.50: Samuel Gerritz (Brystol –Myers Squibb, USA) : "Chemical and Biological Analysis of Combinatorial Libraries”
10.00 – 10.50: Lester Marrison (Evotec OAI): “Automation for solution phase libraries”
11.00 – 11.20: coffee break
11.30 – 12.20: Andrea Porcheddu (Università di Sassari, I): “Cellulose and other polar supports in polymer assisted synthesis”
13.00: lunch
15.00: lab session at University of Siena
20.00: dinner
21.00: farewell
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